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A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health

Philip D Chilibeck, Darren G Candow, Julianne J Gordon, Whitney R D Duff, Riley Mason, Keely Shaw, Regina Taylor-Gjevre, Bindu Nair, Gordon A Zello
Med Sci Sports Exerc 2023 55(10):1750-1760

Bibliography

PubMed
PMID 37144634
PubMed Central
PMC10487398
Funding
Funded by the Canadian Institutes of Health Research and the Canada Foundation for Innovation.
Competing interests
Darren Candow disclosed industry-sponsored creatine research, creatine donations, travel support, AlzChem scientific-advisory-board service and expert-witness/consulting work.

Study snapshot

DesignTwo-year randomized placebo-controlled trial alongside resistance training and walking
ModelHuman
Sample237 postmenopausal women, mean age about 59 years
InterventionCreatine monohydrate 0.14 g/kg/day versus placebo plus resistance training 3 days/week and walking 6 days/week
Duration2 years
EndpointsFemoral neck bone mineral density; Hip and lumbar-spine BMD; Proximal femur geometry; Muscle and functional measures

What the study showed, in plain terms

Large, unusually long creatine trial examining bone outcomes in postmenopausal women during an exercise program.

Key findings

Creatine did not improve femoral-neck, total-hip or lumbar-spine BMD versus placebo, but several proximal-femur geometry measures favored creatine.

What this study can and cannot tell us

Bone-geometry changes are surrogate structural measures and do not establish fracture reduction; all participants also undertook exercise.

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