Tier 2 — strong

Antibacterial mouthwash blunts oral nitrate reduction and increases blood pressure in treated hypertensive men and women

Catherine P Bondonno, Alex H Liu, Kevin D Croft, Michael J Considine, Ian B Puddey, Richard J Woodman, Jonathan M Hodgson
American Journal of Hypertension 2015 28(5):572–575

Bibliography

PubMed
PMID 25359409
DOI
10.1093/ajh/hpu192
Funding
Not yet independently verified for this record
Competing interests
Not yet independently verified for this record

Study snapshot

DesignRandomized controlled crossover trial
Model15 men and women with treated hypertension, mean age 65
Sample15 adults with treated hypertension
InterventionThree-day antibacterial mouthwash versus water rinse
DurationThree-day mouthwash exposure in randomized crossover design
EndpointsOral nitrate reduction; salivary and plasma nitrite; cyclic GMP; blood pressure

What the study showed, in plain terms

Antibacterial mouthwash reduced oral nitrate conversion and produced a small blood-pressure rise compared with water.

Key findings

Antibacterial mouthwash reduced oral nitrate conversion and produced a small blood-pressure rise compared with water.

What this study can and cannot tell us

Only fifteen treated hypertensive participants and a three-day intervention; should not replace evidence-based oral care.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction