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Acute Creatine Ingestion Before Resistance Training Enhances Strength Performance More than Ingestion During or After Training: A Randomized Crossover Pilot Trial

Khouloud Ben Maaoui, Slaheddine Delleli, Arwa Jebabli, Nourhène Mahdi, Juan Del Coso, Hamdi Chtourou, Luca Paolo Ardigò, Ibrahim Ouergui
Nutrients 2026 18(11):1789

Bibliography

PubMed
PMID 42280432
PubMed Central
PMC13258838
Funding
The authors reported no external funding.
Competing interests
The authors declared no conflicts of interest.

Study snapshot

DesignRandomized placebo-controlled crossover pilot trial
ModelHuman
Sample11 physically active men
InterventionSingle 0.1 g/kg creatine monohydrate dose before, during or after resistance exercise, plus placebo and no-supplement conditions
DurationAcute crossover sessions
EndpointsBench-press total load; Back-squat total load; Countermovement jump; Cognition; Perceived recovery; Muscle soreness; Blood biomarkers

What the study showed, in plain terms

Small crossover experiment testing whether a single creatine dose immediately before, during or after one resistance-training session changes acute performance.

Key findings

Pre-exercise creatine was associated with greater bench-press and back-squat total load than placebo/control, while countermovement jump, cognition, exertion, recovery and soreness did not differ across conditions.

What this study can and cannot tell us

Only 11 men; acute single-dose design; exploratory findings, possible expectancy/blinding issues and no tissue-creatine measurements mean this should not overturn the broader evidence that chronic consistency matters more than precise timing.

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