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Effects of combined versus single supplementation of creatine and beta-alanine on aerobic and anerobic performance: a systematic review and network meta-analysis

Xuebing Bai, Tailong Xu
J Int Soc Sports Nutr 2026 23(1):2695133

Bibliography

PubMed
PMID 42384726
Funding
No clear conventional funding statement was located; the accessible publisher record states no commercial or financial affiliation interpreted as a conflict of interest.
Competing interests
The authors reported no commercial or financial affiliations that could be interpreted as a potential conflict of interest.

Study snapshot

DesignSystematic review and network meta-analysis
ModelHuman
Sample52 randomized controlled trials
InterventionCreatine, beta-alanine or combined creatine plus beta-alanine for at least 2 weeks
DurationVaried by included trial; minimum 2 weeks
EndpointsSprint; Jump; Repeated-sprint ability; Agility; Upper-body muscular endurance; Lower-body muscular endurance

What the study showed, in plain terms

Network meta-analysis comparing creatine, beta-alanine and their combination across multiple high-intensity exercise outcomes.

Key findings

Creatine alone showed the most consistent improvements in sprint, jump, repeated-sprint ability and upper-body muscular endurance. Combined creatine plus beta-alanine did not show a clear synergistic advantage.

What this study can and cannot tell us

Network estimates combine direct and indirect comparisons across heterogeneous sports, doses and tasks; some outcomes showed heterogeneity and potential publication bias.

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