Tier 3 — preclinical

Health functionality of apigenin: a review

Ali F, Rahul, Naz F, Jyoti S, Siddique YH
International Journal of Food Properties 2017 20(6):1197-1238

Bibliography

DOI
10.1080/10942912.2016.1207188
Funding
Not stated in the available abstract.
Competing interests
Not stated in the available abstract.

Study snapshot

DesignNarrative review
ModelMixed: in vitro, animal, and limited human data summarised
SampleNot applicable (review)
InterventionNot applicable (review of existing apigenin literature)
DurationNot applicable (review)
EndpointsAntioxidant activity; Anti-inflammatory activity; Bioavailability and metabolism

What the study showed, in plain terms

This review covers apigenin's general health properties, including its antioxidant and anti-inflammatory activity and its poor oral bioavailability due to rapid metabolism. It draws mainly on laboratory and animal research.

Key findings

Apigenin exhibits antioxidant, anti-inflammatory, and other bioactive properties across a range of preclinical models, but its oral bioavailability is limited by extensive first-pass metabolism (glucuronidation and sulfation), consistent with other flavonoids in this class.

What this study can and cannot tell us

Narrative review, not a systematic review or meta-analysis. Not indexed in PubMed (food-science journal, outside PubMed's biomedical scope) — verified via the publisher rather than PubMed. Most evidence discussed is preclinical rather than from completed human trials.

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Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology