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Comparative Efficacy and Pharmacokinetic Parameters of Micronized Creatine Monohydrate (KleanCREATINE™) in Active Men: A Randomized, Controlled Clinical Study

Pravin Aggarwal, Ramshyam Agarwal

Cureus 2026 18(2):e103091

Bibliography

PubMed: PMID 41809290
PubMed Central: PMC12968080
DOI: 10.7759/cureus.103091
Funding: All trial-related expenses and investigational-product expenses were borne by Lasons India Pvt. Ltd.
Competing interests: Pravin Aggarwal reported employment with Lasons India Pvt. Ltd., which funded the trial and investigational product. The other author declared no conflict of interest.

Study snapshot

Design	Two-phase randomized controlled clinical study: open-label crossover pharmacokinetics plus double-blind parallel efficacy phase
Model	Human evidence synthesis or trial
Sample	10 active men in the crossover pharmacokinetic phase; 52 active men in the eight-week parallel efficacy phase
Intervention	3 g/day KleanCREATINE micronized creatine monohydrate versus a marketed creatine monohydrate
Duration	Single-dose pharmacokinetic phase plus 8-week efficacy phase
Endpoints	Plasma creatine pharmacokinetics; Relative bioavailability; Strength; Muscle endurance; Body composition; Perceived exertion; Safety

What the study showed, in plain terms

2026 sponsor-funded study comparing a branded micronized monohydrate with another marketed monohydrate in active men.

Key findings

The study reported higher plasma exposure and faster peak concentration with the micronized product and several favorable training-related outcomes over eight weeks. The study did not measure intramuscular creatine and requires independent replication.

What this study can and cannot tell us

Small pharmacokinetic sample, modest eight-week efficacy sample, men only, sponsor funding and author employment, exploratory sample-size justification, and no direct measurement of muscle creatine stores.

Citation network

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Biohack Blueprint analyses that reference this study in their evidence base.

Oct 2, 2026 Micronized Creatine Monohydrate: Smaller Particles, Same Creatine?Micronized creatine explained: what micronization changes, what it does not change, mixing and stomach claims, and whether it is worth paying more.Read analysis

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Last verified 02 October 2026

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction