Product Review

DoNotAge Pure Apigenin Review

5/5 Editorial score5/5 · BEST OVERALL

5/5 product execution and our #1 overall apigenin pick for readers who want a high-strength, minimal-excipient formula. The rating reflects the product's dose, purity standard, quality-control framework, sourcing and manufacturing—not...

Apigenin, 250 mg per capsule

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By Dr. Khaled Mahmoud, MBBCh

Reviewed by Dr. Amr Yasser, PhD, Dr. Abdulla Mostafa, PhD

· 18 min read

How we scored it

Our editorial recommendation uses a 1–5 scale. We consider the formulation, label clarity, manufacturer quality disclosures, practical use and value for the intended reader. The published rating is an overall editorial judgment; these factors are not separately measured or weighted.

5/5 means a top editorial recommendation for the stated use case. It does not establish clinical effectiveness or mean that we performed laboratory testing. Research strength and safety limitations are assessed separately in this review.

5/5 product-execution rating for high-strength use: 250 mg/capsule, >99% stated batch-release purity, no listed filler blend, batch testing, disclosed sourcing and GMP/ISO9001 manufacturing. Clinical evidence is graded separately.

Read the review summary

Our #1 apigenin supplement and 5/5 formula: 250 mg per capsule, >99% stated batch-purity threshold, no listed filler blend, batch testing, disclosed sourcing and GMP/ISO9001 manufacturing—now benchmarked against the expanded 2026 apigenin market and our evidence library.

5/5 product execution and our #1 overall apigenin pick for readers who want a high-strength, minimal-excipient formula. The rating reflects the product's dose, purity standard, quality-control framework, sourcing and manufacturing—not proof that apigenin has 5/5 clinical efficacy. Direct human evidence for isolated apigenin remains limited, especially for sleep and NAD+ outcomes.

Evidence for an ingredient does not establish the effects of this finished product. See the evidence section for study design, dose and limitations.

DoNotAge Pure Apigenin supplement review, 250 mg apigenin per capsule View image

DoNotAge Pure Apigenin supplement review, 250 mg apigenin per capsule

Read the full editorial assessment

DoNotAge Pure Apigenin is our #1 overall apigenin recommendation for 2026 and earns a 5/5 product-execution rating. Its strongest case is not that the finished product has superior clinical trial evidence—it does not—but that the formula combines 250 mg per capsule, a stated >99% batch-release purity threshold, no listed filler blend, every-batch testing, disclosed grapefruit-derived sourcing and GMP/ISO9001 manufacturing. We also name where competitors are stronger: Nootropics Depot for public lot-level COAs and dose flexibility, and Codeage for an NSF-certified 50 mg liposomal-positioned format.

Formulation strengths and limitations

Key takeaways

  • DoNotAge Pure Apigenin is our #1 overall apigenin recommendation for 2026 and earns a 5/5 product-execution rating for dose strength, formula simplicity, stated purity standard, quality control, sourcing and manufacturing.
  • Each capsule provides a high-strength 250 mg of single-ingredient apigenin, making DoNotAge's stated 500 mg/day routine a simple two-capsule serving.
  • DoNotAge states that every released batch exceeds 99% purity, uses no listed fillers beyond the vegetable cellulose capsule, and makes purity certificates available on request.
  • The source pathway is unusually transparent: grapefruit-derived naringin is converted to apigenin, backed by DoNotAge's stated GMP and ISO9001 manufacturing systems.
  • The 5/5 score rates the product, not the certainty of apigenin's clinical effects: no finished-product human trial has shown that DoNotAge Pure Apigenin improves sleep, raises NAD+ or slows aging.
Physician-reviewed 5/5 formula #1 overall apigenin Best high-strength formula >99% stated batch purity No listed filler blend Batch tested GMP / ISO9001 BB10 saves 10%

Formulation

Key facts & composition

Active ingredient Apigenin, 250 mg per capsule Manufacturer product page verified 14 October 2026.
Recommended serving 500 mg/day (2 capsules) DoNotAge's current standard daily routine; two capsules deliver 500 mg of its high-purity single-ingredient formula.
Purity & testing >99% batch purity threshold DoNotAge states every batch is tested and certificates are available on request.
Other ingredients Vegetable cellulose capsule; no fillers listed Simple single-ingredient formula.
Source Grapefruit-derived naringin → apigenin DoNotAge discloses a synthetic conversion step from grapefruit-derived naringin; the current product page does not identify this as a whole-botanical extract.
Manufacturing GMP / ISO9001; vegan Manufacturer-reported quality-system information.

Composition

Ingredient Amount Form Source
Apigenin 500 mg (two 250 mg capsules) Apigenin powder in a vegetable cellulose capsule; no filler blend is listed on the current manufacturer page. Grapefruit-derived naringin converted to apigenin through a synthetic process.

The 250 mg capsule is a high-strength standard oral format with a simple single-ingredient profile. Human pharmacokinetic research confirms oral apigenin exposure and extensive metabolism, making consistent ingredient identity, purity and dosing especially valuable product attributes.

Who this is for

Good fit if you're...

You want a high-strength apigenin formula without swallowing several capsules

Each capsule provides 250 mg apigenin, so a 250–500 mg/day routine takes one or two capsules rather than several low-dose capsules.

You prioritize a clear purity standard and simple quality-control story

DoNotAge states that every batch is tested and released only when apigenin purity is above 99%, with purity certificates available on request.

You want a minimal-excipient, single-ingredient capsule

The current formula lists apigenin inside a vegetable cellulose capsule with no filler blend, which keeps the label unusually simple.

Probably not for you if...

You specifically want to experiment with a 50 mg bedtime dose

A 250 mg capsule does not offer the fine dose control of a dedicated 50 mg product. A lower-dose competitor may fit a sleep-only experiment better.

You insist on a public lot-by-lot COA archive before buying

DoNotAge says purity certificates are available on request. Nootropics Depot currently makes matching lot-level apigenin COAs directly accessible on its product page.

You are pregnant, breastfeeding, have liver disease or take a complex prescription regimen without clinician review

Human high-dose safety and interaction data are not strong enough to treat apigenin as a casual add-on in these situations. Get clinician or pharmacist input first.

How it works

Apigenin is a dietary flavone studied across CD38/NAD+ biology, inhibitory neurotransmission, inflammation and cellular-senescence pathways. DoNotAge delivers it as a high-strength, single-ingredient formula with a stated >99% batch-purity threshold and no listed fillers.

1

CD38 inhibition and NAD+ preservation

Apigenin has inhibited the NAD+-consuming enzyme CD38 in cell and mouse studies, with downstream increases in NAD+ and changes in metabolic, inflammatory and senescence-related pathways. This is a compelling longevity mechanism, but oral supplementation has not yet demonstrated clinically meaningful CD38 inhibition or NAD+ elevation in humans.

2

GABA-related relaxation and sleep signaling

Experimental research links apigenin to benzodiazepine/GABA-related signaling and sleep-promoting effects in animal models. Human sleep evidence is indirect: chamomile trials test a multi-compound botanical, and the 2026 supplement trial combined 50 mg apigenin with magnesium L-threonate and L-theanine.

3

Absorption, metabolism and formulation

Human ADME and parsley-feeding studies show that apigenin-related compounds are absorbed but extensively metabolized. Low water solubility and rapid conjugation mean the capsule dose is not equivalent to unchanged systemic exposure, and product-specific outcome data remain more important than theoretical bioavailability claims.

Research & evidence

24 cited sources · Apigenin Data Center

The evidence

Sources include research papers and other cited records, such as registered trials. A trial registration is not a published result.

We grade claims by what the published evidence supports. Human pharmacokinetic exposure, chamomile trials, combination studies and preclinical apigenin experiments are kept separate so a finding from one evidence category is not silently converted into proof for this finished product.

B Oral apigenin reaches human metabolism and can be measured after isolated or food-derived exposure Tier 1

Direct human ADME and controlled parsley studies confirm absorption and extensive metabolism. This establishes human exposure, not efficacy for sleep, anxiety or longevity.

Gina Borges et al. 2022 , Hellen Meyer et al. 2006 , S. E. Nielsen et al. 1999

D Isolated apigenin improves sleep in humans Tier 4

The direct human evidence is insufficient. Chamomile sleep trials cannot isolate apigenin, dietary observational data cannot prove causality, and the 2026 human supplement trial administered apigenin with magnesium L-threonate and L-theanine rather than alone.

Gianna F. Mastrofini et al. 2026 , Justyna Godos et al. 2020 , Suzanna M. Zick et al. 2011 , Mohsen Adib-Hajbaghery et al. 2017 , Shao-Min Chang et al. 2016

B Apigenin inhibits CD38 and preserves NAD+ in experimental models Tier 2

CD38 inhibition, NAD+ preservation and related downstream biology are supported across cell and mouse studies, including the landmark Escande paper and later senescence/neuroinflammation work. Human target-engagement evidence is still missing.

Escande C et al. 2013 , Jureepon Roboon et al. 2021 , Bing Si Li et al. 2021

D Isolated apigenin reduces clinical anxiety in humans Tier 4

Apigenin has GABA-related and anxiolytic-like preclinical evidence, but the randomized human anxiety trials involve chamomile extracts containing many constituents. There is no validated isolated-apigenin treatment effect or dose.

Jin Wang et al. 2026 , H. Viola et al. 1995 , Jay D Amsterdam et al. 2009 , Jun J Mao et al. 2016

C High-dose long-term apigenin supplementation is established as safe in healthy adults Tier 3

Human exposure and hemostasis studies are informative, but long-term high-dose isolated-apigenin safety data are limited. Laboratory drug-interaction signals and mouse liver-toxicity findings justify caution rather than assuming food occurrence guarantees supplement-dose safety.

K Janssen et al. 1998 , Prabhat Singh et al. 2012 , Łukasz S. Jarosz et al. 2025 , Ting Wu et al. 2017 , Yuka Kimura et al. 2010

Verified 14 October 2026 against DoNotAge's current Pure Apigenin product information and the 67-paper Apigenin Research Data Center. Current retail lot not independently assayed by Biohack Blueprint.

Comparison

How it compares

DoNotAge Pure Apigenin SupplementNootropics Depot Apigenin Codeage Liposomal Apigenin
Dose per capsule 250 mg 50 mg or 200 mg 50 mg
Purity / standardization claim Brand states every batch must exceed 99% purity before release Minimum 98% apigenin NSF Certified for purity, potency and label accuracy; no >99% assay threshold stated
Testing visibility Every-batch testing stated; purity certificates available on request Public lot-matched COA archive on product page NSF Certified; every batch independently tested
Delivery format Conventional single-ingredient apigenin capsule Conventional apigenin capsule Helix phospholipid / liposomal-positioned capsule
Low-dose flexibility Low: 250 mg is the minimum whole-capsule dose High: 50 mg and 200 mg options High: 50 mg per capsule
High-strength convenience Excellent: 250 mg per capsule; 500 mg is two capsules Strong: up to 200 mg per capsule Low for high-dose use: 50 mg per capsule
Manufacturing / quality framework GMP and ISO9001 standards stated by brand cGMP / FDA-registered facility language; ISO-accredited lab testing USA cGMP-certified facility plus NSF certification

Clinical pharmacology

DoNotAge provides 250 mg per capsule and currently recommends 500 mg/day. Human pharmacokinetic research confirms oral apigenin exposure and extensive metabolism, while the product's high-strength two-capsule routine keeps daily use simple and consistent.

Dose tiers

TierDoseFrequencyDurationNotes
One-capsule option (250 mg/day) 250 mg/day (1 capsule) Once daily Ongoing, if used

DoNotAge offers this one-capsule daily option for users who prefer the simplest entry point to the same high-purity, filler-free formula.
Recommended routine (500 mg/day) 500 mg/day (2 capsules) Daily Ongoing, according to current label guidance

This is DoNotAge's current recommended daily serving. Two 250 mg capsules deliver 500 mg while keeping the routine straightforward and consistent.
Higher-intake manufacturer options (750–1,000 mg/day) 750–1,000 mg/day (3–4 capsules) Daily Manufacturer subscription options, not an evidence-based recommendation

DoNotAge offers subscription configurations corresponding to 750–1,000 mg/day, but availability is not proof that these higher intakes improve outcomes or are appropriate for routine use. Long-term high-dose human safety data are limited; clinician or pharmacist review is sensible before escalating, especially with medicines or medical conditions.

From bench to bedside

PathwayPreclinical findingHuman translationConfidence
CD38 inhibition / NAD+ preservation Apigenin inhibits CD38 in experimental models, with increases in NAD+ and downstream metabolic, inflammatory or senescence-related changes. Human oral supplementation has not yet demonstrated clinically meaningful CD38 inhibition or a reproducible NAD+ increase attributable to apigenin. Emerging
GABA-related relaxation signaling Apigenin interacts with benzodiazepine/GABA-related signaling and produces anxiolytic-like or sleep-promoting effects in several experimental models. Chamomile has human anxiety/sleep studies, but purified apigenin lacks direct clinical efficacy trials establishing a treatment effect or dose. Preliminary
Oral absorption and metabolism Formulation and gut metabolism strongly alter apigenin exposure; enhanced-delivery systems can increase bioavailability in preclinical studies. Human ADME and parsley studies confirm absorption and extensive metabolism, but better exposure has not yet been linked to better clinical outcomes. Moderate

Drug interactions

Potential interaction

CYP3A4 / CYP2C9 substrates

Laboratory research has reported inhibition of human CYP3A4 and CYP2C9 activity by apigenin/polyphenols, creating a theoretical risk of altered exposure to susceptible medicines.

Recommendation:

If you use medicines with a narrow therapeutic window or major CYP3A4/CYP2C9 dependence, review concentrated apigenin with a pharmacist or prescribing clinician rather than assuming the food-supplement distinction is irrelevant.

Potential interaction

OAT1-transported medicines

Preclinical research identifies apigenin as a potential inhibitor/interactor with organic anion transporter 1 (OAT1), which contributes to renal handling of some medicines.

Recommendation:

Use clinician or pharmacist review when taking prescription medicines with important renal transporter dependence, especially if considering high-dose daily apigenin.

Caution

Sedating medicines and sleep supplements

Apigenin has inhibitory/GABA-related preclinical pharmacology and is commonly used in sleep stacks, so additive drowsiness with other sedating agents is biologically plausible even though a formal interaction magnitude is not established.

Recommendation:

Avoid introducing multiple sedating agents simultaneously. Monitor next-day alertness and obtain medical advice if you use prescription sedatives, sleep medicines or other centrally acting drugs.

Bioavailability tips

Apigenin has low water solubility and is extensively metabolized. Consistent use with food is a practical approach for a standard oral capsule. DoNotAge's simple 250 mg format makes the delivered amount clear without relying on a proprietary blend or an unquantified botanical extract.

Special populations

PopulationRecommendationRationale
Pregnancy and breastfeeding Avoid routine high-dose supplementation

Adequate human safety data for concentrated apigenin during pregnancy or breastfeeding are lacking. Food-level exposure is not equivalent to a 250–500 mg supplement regimen.
People taking prescription medicines Medication review recommended

Laboratory evidence involving CYP3A4, CYP2C9 and OAT1 creates a plausible interaction concern, especially with medicines that have narrow therapeutic windows or major transporter/enzyme dependence.
Liver disease or unexplained liver-test abnormalities Use clinician guidance

High-dose isolated-apigenin liver safety is not well established in humans, and mouse studies have reported hepatic changes at experimental exposures. This does not prove human hepatotoxicity, but it argues against casual high-dose escalation in higher-risk users.
People using sedatives or multiple sleep aids Start cautiously and avoid stacking blindly

Apigenin's GABA-related experimental pharmacology makes additive drowsiness plausible. Starting several sleep-promoting agents at once also makes benefit and adverse effects difficult to attribute.

Therapeutic positioning

DoNotAge holds our #1 overall position for a high-strength apigenin supplement, but it does not win every niche criterion. Nootropics Depot offers better 50 mg dose flexibility and public lot-level COA access, while Codeage offers an NSF-certified 50 mg liposomal-positioned option. DoNotAge wins our overall ranking because its 250 mg capsule, >99% stated batch-release purity threshold, no listed filler blend, batch testing, disclosed sourcing and GMP/ISO9001 framework create the strongest complete high-strength package.

Nootropics Depot Apigenin

Lower-dose / flexible-dose apigenin DoNotAge #1 overall; Nootropics Depot best for dose flexibility and public COAs

Nootropics Depot is the strongest alternative for dose flexibility and public testing visibility: it currently offers 50 mg and 200 mg capsules, states a minimum 98% purity and publishes lot-matched COAs on the product page. We still rank DoNotAge #1 overall for high-strength use because it combines 250 mg per capsule, a stated >99% batch-release threshold, no listed filler blend and disclosed sourcing/manufacturing standards.

Codeage Liposomal Apigenin

Phospholipid / liposomal-positioned apigenin DoNotAge #1 overall; Codeage strongest certified 50 mg liposomal option

Codeage is the strongest certified low-dose liposomal-positioned alternative we found: 50 mg per capsule, NSF certification, independent batch testing and a sunflower-phospholipid delivery system. We rank DoNotAge higher overall for readers deliberately seeking a high-strength, minimal-excipient formula; Codeage may fit better if 50 mg dosing or NSF-certified liposomal delivery is the priority.

Chamomile tea or extract

Botanical apigenin source DoNotAge #1 dedicated apigenin supplement

Chamomile is a multi-compound botanical and a different evidence category from purified apigenin. DoNotAge provides a precise 250 mg isolated-apigenin dose with batch-purity and manufacturing disclosures, making it our preferred option when the goal is a dedicated apigenin supplement.

Apigenin is an optional supplement layered on top of sleep regularity, light exposure, exercise, nutrition, medication review and management of underlying sleep or anxiety disorders. No apigenin supplement has demonstrated human lifespan extension or replaces evidence-based care.

This product is not a substitute for prescribed treatment, cognitive behavioral therapy for insomnia, anxiety treatment, cancer care, cardiovascular therapy or evaluation of persistent sleep and mood symptoms.

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  • 30 days for a 60-capsule bottle at 500 mg/day; annual subscription format varies by selected daily dose
  • DoNotAge currently offers annual subscription options corresponding to 250, 500, 750 or 1,000 mg/day, giving users several high-strength intake options within the same clean formula.
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About buying through us

Why is DoNotAge Pure Apigenin your #1 overall apigenin pick?

Because it has the strongest complete high-strength package in our comparison: 250 mg per capsule, a brand-stated >99% batch-release purity threshold, no listed filler blend, every-batch testing, disclosed grapefruit-derived sourcing, and GMP/ISO9001 manufacturing. Nootropics Depot has better public lot-level COA visibility and more dose flexibility, while Codeage offers a certified 50 mg liposomal format. Those are real strengths, but for a high-strength, minimal-excipient apigenin product, DoNotAge remains our best overall fit.

What does the 5/5 rating actually mean?

It is our product-execution score for formula simplicity, dose strength, purity standard, quality control, sourcing and manufacturing—not a claim that apigenin has 5/5 clinical efficacy. We do not claim this finished product has been proven in a human trial to improve sleep, raise NAD+, slow aging or treat disease. Evidence certainty is graded separately throughout the review.

Is 250 mg too much if I only want apigenin for sleep?

It is substantially higher than the widely discussed 50 mg bedtime protocol, and there is no universally established evidence-based apigenin dose for sleep. If your goal is specifically a low-dose bedtime experiment, a 50 mg product gives finer control. DoNotAge makes more sense for readers deliberately choosing a high-strength apigenin format.

Why not choose Nootropics Depot Apigenin instead?

Nootropics Depot is one of the strongest alternatives we found. It offers 50 mg and 200 mg options, states a minimum 98% purity and publishes lot-matched COAs directly on the product page. We prefer DoNotAge overall for readers seeking a 250 mg high-strength capsule, a stated >99% batch-release threshold, no listed filler blend and the brand's disclosed sourcing and manufacturing framework. If public COA access or 50 mg dose flexibility is your top priority, Nootropics Depot may fit you better.

Why not buy a liposomal apigenin product instead?

Liposomal and phospholipid delivery systems are scientifically plausible ways to address apigenin's formulation challenges, but we did not find head-to-head human pharmacokinetic or clinical evidence showing that the finished Codeage or Renue By Science apigenin products outperform a conventional high-purity apigenin capsule. We therefore treat liposomal delivery as a formulation feature, not proof of superior clinical effect.

Does DoNotAge Pure Apigenin actually raise NAD+ in humans?

That has not been demonstrated directly. The CD38/NAD+ rationale is compelling mechanistically and supported mainly by cellular and animal work, but no human trial of this finished product has shown that taking DoNotAge Pure Apigenin raises NAD+ or produces a longevity outcome. We separate that mechanism from proven human efficacy throughout this review.

Reader questions

Is DoNotAge Pure Apigenin worth it?

Yes—DoNotAge Pure Apigenin is our #1 overall apigenin pick for 2026. It combines 250 mg per capsule, no listed fillers, a >99% stated batch-purity release threshold, batch testing, disclosed sourcing and GMP/ISO9001 manufacturing in one exceptionally clean formula.

How much DoNotAge Pure Apigenin should you take?

DoNotAge currently recommends 500 mg/day, or two 250 mg capsules, and also offers annual subscription options corresponding to 250, 750 and 1,000 mg/day. Follow the product directions and individualize higher-intake routines with a clinician or pharmacist when medicines or medical conditions are involved.

Why do people choose DoNotAge Pure Apigenin for evening routines?

Apigenin is widely studied for sleep- and relaxation-related biology, and a 2026 human combination trial included 50 mg of apigenin alongside magnesium L-threonate and L-theanine. DoNotAge offers a precise, high-purity isolated-apigenin formula for users who want apigenin as a dedicated ingredient rather than as part of an unstandardized botanical.

Why is apigenin studied for CD38 and NAD+ biology?

Apigenin has inhibited the NAD+-consuming enzyme CD38 and supported NAD+ preservation in experimental models, which is why it has become an important longevity-research compound. DoNotAge provides a precise, high-strength isolated-apigenin format for readers interested in that research pathway.

How is DoNotAge Pure Apigenin tested?

DoNotAge labels Pure Apigenin as third-party tested and states that every batch is tested and supplied only if purity is above 99%, with purity certificates available on request. We treat that as strong quality-control information, while also noting that competitors such as Nootropics Depot make lot-matched COAs public directly on the product page.

What is the Biohack Blueprint DoNotAge discount code?

BB10 currently gives 10% off eligible standalone DoNotAge products. Biohack Blueprint may earn a commission from qualifying purchases made through our DoNotAge links, at no extra cost to the reader.

Editorial credibility

Portrait of Dr. Khaled Mahmoud, ICU physician and founder of Biohack Blueprint

Author

Dr. Khaled Mahmoud, MBBCh

MBBCh

Critical Care Medicine, Longevity Science & Editorial Direction

Portrait of Dr. Amr Yasser, cardiometabolic and musculoskeletal reviewer for Biohack Blueprint

Reviewer

Dr. Amr Yasser, PhD

MBBCh, PhD, General Surgery, Cardiometabolic Medicine, Musculoskeletal Research

Cardiometabolic, Musculoskeletal, Gut & Bioavailability

Portrait of Dr. Abdulla Mostafa, neuroscience reviewer for Biohack Blueprint

Reviewer

Dr. Abdulla Mostafa, PhD

MBBCh, PhD, Neuroscience, Neurosurgery

Cellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology

5/5 product-execution rating for high-strength use: 250 mg/capsule, >99% stated batch-release purity, no listed filler blend, batch testing, disclosed sourcing and GMP/ISO9001 manufacturing. Clinical evidence is graded separately.

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Related reading

Apigenin Benefits: What It Is, What It Does & What the Science Says

Apigenin for Sleep: Does It Actually Work?

Apigenin Dosage: How Much Should You Take?

Apigenin Side Effects, Safety & Drug Interactions

Foods High in Apigenin: Best Natural Sources

Apigenin in Chamomile: How Much Is There and Does Chamomile Help Sleep?

Apigenin Bioavailability: Absorption, Metabolism & How to Take It

Liposomal Apigenin: Is It Better Absorbed?

Best Apigenin Supplements in 2026

Apigenin vs Melatonin: Which Is Better for Sleep?

Apigenin Sleep Stack: Magnesium, L-Theanine, Glycine & More

Apigenin, CD38 & NAD+: What It Could Mean for Longevity

Apigenin for Anxiety and Relaxation: What Does the Evidence Show?
  1. Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults Gina Borges, Reedmond Y. Fong, Jodi L. Ensunsa, Jennifer Kimball, Valentina Medici, Javier I. Ottaviani, Alan Crozier (2022) . Free Radical Biology and Medicine Read on our Data CenterView on PubMed DOI Clinical Trial
  2. Bioavailability of apigenin from apiin-rich parsley in humans Hellen Meyer, Adrian Bolarinwa, Guenther Wolfram, Jakob Linseisen (2006) . Annals of Nutrition and Metabolism Read on our Data CenterView on PubMed DOI
  3. Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects S. E. Nielsen, J. F. Young, B. Daneshvar, S. T. Lauridsen, P. Knuthsen, B. Sandström, L. O. Dragsted (1999) . British Journal of Nutrition Read on our Data CenterView on PubMed DOI
  4. Modulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled trial Gianna F. Mastrofini, Riccardo F. Romersi, Maria G. Lombardi, Katelynn T. Persaud, Monica M. Ryan, Katie R. Hirsch, Amy L. Fraley, J. Jay Dawes, Sten O. Stray-Gundersen, James W. Hardin, Shawn M. Arent (2026) . Journal of the International Society of Sports Nutrition Read on our Data CenterView on PubMed View on PMC DOI
  5. Synergistic sleep-promoting effects of magnesium and apigenin in normal and insomnia mouse models Wing-Yan Wong, Brandon Dow Chan, Hengshen Zhou, Tsz Chun Leung, William Chi-Shing Tai (2026) . Food & Function Read on our Data CenterView on PubMed DOI
  6. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN (2013) . Diabetes Read on our Data CenterView on PubMed DOI
  7. Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD+ Jureepon Roboon, Tsuyoshi Hattori, Hiroshi Ishii, Mika Takarada-Iemata, Dinh Thi Nguyen, Collin D Heer, Denis O'Meally, Charles Brenner, Yasuhiko Yamamoto, Hiroshi Okamoto, Haruhiro Higashida, Osamu Hori (2021) . Journal of Neurochemistry Read on our Data CenterView on PubMed View on PMC DOI
  8. Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD+-CD38 Axis Bing Si Li, Ri Zhe Zhu, Seok-Hee Lim, Jae Ho Seo, Byung-Min Choi (2021) . American Journal of Chinese Medicine Read on our Data CenterView on PubMed DOI
  9. Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38 Knut Husø Lauritzen, Kuan Yang, Michael Frisk, Mieke C. Louwe, Maria Belland Olsen, Mathias Ziegler, William E. Louch, Bente Halvorsen, Pål Aukrust, Arne Yndestad, Øystein Sandanger (2025) . Frontiers in Immunology Read on our Data CenterView on PubMed View on PMC DOI
  10. Apigenin for Depression and Anxiety: A Systematic Review of Preclinical Studies Jin Wang, Kun Shi (2026) . Iranian Journal of Pharmaceutical Research Read on our Data CenterView on PubMed View on PMC DOI
  11. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects H. Viola, C. Wasowski, M. Levi de Stein, C. Wolfman, R. Silveira, F. Dajas, J. H. Medina, A. C. Paladini (1995) . Planta Medica Read on our Data CenterView on PubMed DOI
  12. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla R. Avallone, P. Zanoli, G. Puia, M. Kleinschnitz, P. Schreier, M. Baraldi (2000) . Biochemical Pharmacology Read on our Data CenterView on PubMed DOI
  13. Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors Juan D. Goutman, Maximiliano D. Waxemberg, Francisco Doñate-Oliver, Pablo E. Pomata, Daniel J. Calvo (2003) . European Journal of Pharmacology Read on our Data CenterView on PubMed DOI
  14. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder Jay D Amsterdam, Yimei Li, Irene Soeller, Kenneth Rockwell, Jun James Mao, Justine Shults (2009) . Journal of Clinical Psychopharmacology Read on our Data CenterView on PubMed View on PMC DOI
  15. Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial Jun J Mao, Sharon X Xie, John R Keefe, Irene Soeller, Qing S Li, Jay D Amsterdam (2016) . Phytomedicine Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  16. Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and meta-analysis of randomized trials and quasi-randomized trials Truong Hong Hieu, Mahmoud Dibas, Kadek Agus Surya Dila, Nourin Ali Sherif, Muhammad Usman Hashmi, Mostafa Mahmoud, Nguyen Thi Thuy Trang, Lava Abdullah, Thai Le Ba Nghia, Mai Nhu Y, Kenji Hirayama, Nguyen Tien Huy (2019) . Phytotherapy Research Read on our Data CenterView on PubMed DOI
  17. Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study K Janssen, R P Mensink, F J Cox, J L Harryvan, R Hovenier, P C Hollman, M B Katan (1998) . The American journal of clinical nutrition Read on our Data CenterView on PubMed DOI
  18. Acute exposure of apigenin induces hepatotoxicity in Swiss mice Prabhat Singh, Shrawan Kumar Mishra, Sanjeev Noel, Sharad Sharma, Srikanta Kumar Rath (2012) . PLoS ONE Read on our Data CenterView on PubMed View on PMC DOI
  19. Subacute exposure to apigenin induces changes in protein synthesis in the liver of Swiss mice Łukasz S. Jarosz, Katarzyna Socała, Katarzyna Michalak, Kamila Bulak, Artur Ciszewski, Agnieszka Marek, Zbigniew Grądzki, Piotr Wlaź, Edyta Kowalczuk-Vasilev, Anna Rysiak (2025) . Frontiers in Physiology Read on our Data CenterView on PubMed View on PMC DOI
  20. Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1) Ting Wu, Haixin Li, Jiasheng Chen, Ying Cao, Weimin Fu, Pingzheng Zhou, Jianxin Pang (2017) . Pharmacological Reports Read on our Data CenterView on PubMed DOI
  21. Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity Yuka Kimura, Hideyuki Ito, Ryoko Ohnishi, Tsutomu Hatano (2010) . Food and Chemical Toxicology Read on our Data CenterView on PubMed DOI
  22. Enhancement of in vitro transcellular absorption and in vivo oral bioavailability of apigenin by self-nanoemulsifying drug delivery systems Vilasinee Hirunpanich Sato, Hitoshi Sato, Manaw Sangfuang, Jannarin Nontakham, Varaporn Buraphacheep Junyaprasert, Veerawat Teeranachaideekul, Boontida Morakul (2024) . Scientific Reports Read on our Data CenterView on PubMed View on PMC DOI
  23. Enhancing therapy with nano-based delivery systems: exploring the bioactive properties and effects of apigenin Girish Kumar, Pushpika Jain, Tarun Virmani, Ashwani Sharma, Md Sayeed Akhtar, Saad A. Aldosari, Mohd Faiyaz Khan, Sofia O. D. Duarte, Pedro Fonte (2024) . Therapeutic Delivery Read on our Data CenterView on PubMed View on PMC DOI
  24. Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives Peng Chen, Fuchao Chen, ZhiLei Guo, Jiexin Lei, Benhong Zhou (2023) . Frontiers in Nutrition Read on our Data CenterView on PubMed View on PMC DOI
  • 14 Oct 2026 Updated 14 October 2026: expanded product-selection guidance, competitor comparison, objection handling, safety context, guarantee information and evidence framing after re-verifying current manufacturer information.
First published 14 Oct 2026 · Last verified 14 Oct 2026