{"product_id":"pure-tmg-supplement","title":"DoNotAge Pure TMG","description":"\u003cp\u003eBiohack Blueprint is a DoNotAge affiliate. We may earn a commission when you buy through our links. BB10 is our reader discount code for eligible purchases; checkout confirms the discount and any exclusions or stacking rules.\u003c\/p\u003e\n\u003ch2\u003eOur 5\/5 verdict\u003c\/h2\u003e\n\u003cp\u003eOur editorial rating is 5\/5 for the capsule offering: a single active ingredient, clearly declared 500 mg units, a plant-based shell, 60\/366-capsule pack choices and straightforward serving arithmetic. It is our preferred plain TMG capsule for adults who have a suitable reason to use betaine anhydrous.\u003c\/p\u003e\n\u003cp\u003eThis is a label and research review. It does not claim that Pure TMG has been proven to reverse aging, treat liver disease or make NMN mandatory. The score describes our product preference; evidence for individual health outcomes is assessed below.\u003c\/p\u003e\n\u003ch2\u003eFormula, serving and price\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eDetail\u003c\/th\u003e\n\u003cth\u003eValue\u003c\/th\u003e\n\u003cth\u003eContext\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eActive ingredient\u003c\/th\u003e\n\u003ctd\u003eTrimethylglycine (betaine anhydrous)\u003c\/td\u003e\n\u003ctd\u003eTMG and glycine betaine are names for the same compound.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePer capsule\u003c\/th\u003e\n\u003ctd\u003e500 mg TMG\u003c\/td\u003e\n\u003ctd\u003eA single capsule contains 0.5 g.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eListed daily serving\u003c\/th\u003e\n\u003ctd\u003e1,000 mg: two capsules\u003c\/td\u003e\n\u003ctd\u003eThe current product-page serving is used for our pack-duration arithmetic; follow the label supplied with your order.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eCapsule and other ingredients\u003c\/th\u003e\n\u003ctd\u003eHypromellose vegetable cellulose\u003c\/td\u003e\n\u003ctd\u003eManufacturer describes TMG inside a vegan capsule without additional active ingredients.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eOne-time pack choices\u003c\/th\u003e\n\u003ctd\u003e60 or 366 capsules\u003c\/td\u003e\n\u003ctd\u003e30 or 183 days at two capsules daily.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eUS displayed one-time prices\u003c\/th\u003e\n\u003ctd\u003eUS$20 \/ US$95\u003c\/td\u003e\n\u003ctd\u003e60 \/ 366 capsules; checked 18 October 2026 before shipping, tax and discounts.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eUK displayed one-time prices\u003c\/th\u003e\n\u003ctd\u003e£16 \/ £76\u003c\/td\u003e\n\u003ctd\u003e60 \/ 366 capsules; regional checkout terms apply.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eCanadian displayed one-time prices\u003c\/th\u003e\n\u003ctd\u003eCA$29 \/ CA$136\u003c\/td\u003e\n\u003ctd\u003e60 \/ 366 capsules; confirm delivery, taxes and final checkout terms for your address.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eTesting information\u003c\/th\u003e\n\u003ctd\u003eCertificates available on request, per manufacturer\u003c\/td\u003e\n\u003ctd\u003eAsk for the current TMG lot document. We did not independently assay the retail lot.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eValue at the listed daily serving\u003c\/h2\u003e\u003cp\u003eThe smaller pack contains 30 g total TMG and the larger pack contains 183 g. At the displayed US one-time prices of $20 and $95, these work out to about $0.67 and $0.52 per gram, respectively, before delivery, tax or discounts. The two-capsule serving makes the same figures the ingredient cost per listed day. The larger pack lowers the per-gram price; the smaller pack lowers the initial commitment.\u003c\/p\u003e\u003cp\u003eA bulk powder may be less expensive per gram, while a fixed capsule avoids weighing each portion. Our 5\/5 score reflects the capsule offering and editorial preference. It does not claim independent batch testing, superiority in a human trial or equal certainty for every proposed benefit.\u003c\/p\u003e\n\u003ch2\u003eWhat the human evidence supports\u003c\/h2\u003e\n\u003cp\u003eThe research below concerns the ingredient and specified study formulations. We did not identify a published trial proving that the current Pure TMG retail capsule outperforms equivalent betaine anhydrous products. We assess the product’s formula and convenience separately from the certainty of each health claim.\u003c\/p\u003e\n\u003cp\u003eThe broader 415-publication Data Center includes supporting, null and unfavorable results, companion reports, observational associations and animal experiments. The selected papers in this review are the ones relevant to the claims being assessed.\u003c\/p\u003e\n\u003ch3\u003eHuman trials demonstrate a homocysteine-lowering effect\u003c\/h3\u003e\n\u003cp\u003eControlled trials support a biomarker effect in defined populations. The amount and duration matter; this does not establish fewer heart attacks or strokes. Some higher-dose studies also report lipid increases. \u003ca href=\"\/blogs\/research\/tmg-14652361\"\u003eStudy 14652361\u003c\/a\u003e \u003ca href=\"\/blogs\/research\/tmg-12730412\"\u003eStudy 12730412\u003c\/a\u003e \u003ca href=\"\/blogs\/research\/tmg-33764214\"\u003eStudy 33764214\u003c\/a\u003e \u003ca href=\"\/blogs\/research\/tmg-15916468\"\u003eStudy 15916468\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eSome strength outcomes favor betaine, with mixed results overall\u003c\/h3\u003e\n\u003cp\u003eA 2024 synthesis favored maximal strength, while several other performance outcomes did not clearly improve. Small training trials include both favorable and null findings. A daily study protocol does not establish an immediate pre-workout effect. \u003ca href=\"\/blogs\/research\/tmg-39514262\"\u003eStudy 39514262\u003c\/a\u003e \u003ca href=\"\/blogs\/research\/tmg-23967897\"\u003eStudy 23967897\u003c\/a\u003e \u003ca href=\"\/blogs\/research\/tmg-30064450\"\u003eStudy 30064450\u003c\/a\u003e \u003ca href=\"\/blogs\/research\/tmg-32516959\"\u003eStudy 32516959\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eBody-composition results are inconsistent\u003c\/h3\u003e\n\u003cp\u003eAn earlier meta-analysis reported favorable fat-mass findings, but a later synthesis found no overall body-composition benefit. This product should not be selected on a promise of reliable weight loss. \u003ca href=\"\/blogs\/research\/tmg-31623137\"\u003eStudy 31623137\u003c\/a\u003e \u003ca href=\"\/blogs\/research\/tmg-34743773\"\u003eStudy 34743773\u003c\/a\u003e \u003ca href=\"\/blogs\/research\/tmg-12399266\"\u003eStudy 12399266\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eLiver-treatment benefits remain unestablished\u003c\/h3\u003e\n\u003cp\u003eThe corrected conclusion of the placebo-controlled NASH trial did not establish improved steatosis versus placebo. Newer pilot enzyme findings are exploratory and do not establish a treatment effect. \u003ca href=\"\/blogs\/research\/tmg-19824078\"\u003eStudy 19824078\u003c\/a\u003e \u003ca href=\"\/blogs\/research\/tmg-40758380\"\u003eStudy 40758380\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eHealthy-aging mechanisms are an active research area\u003c\/h3\u003e\n\u003cp\u003eThe prominent exercise-and-betaine geroprotection study profiled humans during exercise but tested direct betaine aging interventions in mice. It does not demonstrate age reversal from a TMG capsule in humans. \u003ca href=\"\/blogs\/research\/tmg-40570836\"\u003eStudy 40570836\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eUsing the product\u003c\/h2\u003e\n\u003cp\u003eResearch amounts, product servings and prescription regimens are different categories. The table describes their context and should not be used as a dose-escalation schedule. One gram equals 1,000 mg.\u003c\/p\u003e\n\u003cp\u003eTake with water according to the label. The manufacturer FAQ permits use with or without food; a meal can be a practical tolerance choice. A superior clock time or required fasting window has not been established.\u003c\/p\u003e\n\u003cp\u003eKeep the bottle closed in a cool, dry place away from heat and direct sunlight. Refrigeration is not required by the manufacturer. For powders or other formats, use their own storage and measurement instructions.\u003c\/p\u003e\n\u003cp\u003eDigestive symptoms can occur, and some gram-level trials report higher blood lipids. Suitability depends on the reason for use, the actual daily amount and the person’s medical context.\u003c\/p\u003e\n\u003cp\u003eNot a substitute for treatment of elevated homocysteine, nutrient deficiency, hypertension or liver disease. Pregnancy, breastfeeding, children, kidney disease and inherited metabolic disorders require individual assessment. Use prescription betaine only under specialist instructions.\u003c\/p\u003e\n\u003ch2\u003eQuestions before buying\u003c\/h2\u003e\n\u003ch3\u003eHow much TMG is in each capsule?\u003c\/h3\u003e\n\u003cp\u003e500 mg, which is 0.5 g. The manufacturer’s product page lists a 1,000 mg daily serving, so that serving consists of two capsules. Follow the current label supplied with your order.\u003c\/p\u003e\n\u003ch3\u003eHow long does a 60- or 366-capsule bottle last?\u003c\/h3\u003e\n\u003cp\u003eAt two capsules daily, 60 capsules last 30 days and 366 capsules last 183 days. At one capsule daily, they last 60 and 366 days. The 1 g\/day annual subscription describes two larger bottles.\u003c\/p\u003e\n\u003ch3\u003eWhy is the review rated 5\/5?\u003c\/h3\u003e\n\u003cp\u003eThe editorial score reflects our preference for the single-active formula, clear 500 mg units, vegan shell, practical serving and pack choices. It is a label and research assessment, not a customer average, personal-use trial or clinical efficacy score.\u003c\/p\u003e\n\u003ch3\u003eWas this exact retail product tested in all the research papers?\u003c\/h3\u003e\n\u003cp\u003eNo. The Data Center contains research on betaine and related questions across different formulations and populations. The cited ingredient studies do not establish superior outcomes for the current retail capsule.\u003c\/p\u003e\n\u003ch3\u003eDo I need TMG if I use NMN?\u003c\/h3\u003e\n\u003cp\u003eA universal need and a validated 1:1 ratio have not been established. The pairing has a biochemical rationale, but each product should have a suitable reason for use.\u003c\/p\u003e\n\u003ch3\u003eWhat testing documents can I request?\u003c\/h3\u003e\n\u003cp\u003eDoNotAge states that certificates of analysis are available on request. Ask for the current TMG lot, the testing laboratory and the results relevant to identity, potency and contamination. We did not independently assay the retail lot.\u003c\/p\u003e\n\u003ch3\u003eHow does BB10 work?\u003c\/h3\u003e\n\u003cp\u003eEnter BB10 at the DoNotAge checkout for 10% off eligible orders. Confirm the displayed discount, purchase-option terms, shipping and any stacking restrictions before paying.\u003c\/p\u003e\n\u003ch3\u003eCan I take it with food?\u003c\/h3\u003e\n\u003cp\u003eThe manufacturer FAQ permits use with or without food. A meal can be convenient if it improves tolerance. No universally superior clock time has been established.\u003c\/p\u003e\n\u003ch3\u003eIs it vegan?\u003c\/h3\u003e\n\u003cp\u003eThe manufacturer describes the product as vegan and identifies a hypromellose vegetable-cellulose capsule. Check the current label for the product shipped to your market.\u003c\/p\u003e\n\u003ch3\u003eIs it a fatty-liver or weight-loss treatment?\u003c\/h3\u003e\n\u003cp\u003eThose clinical uses are not established for this product. Read the separate liver and body-composition guides for the human evidence and its limits.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/donotage.org\/pure-tmg?dna_link=1170\" rel=\"sponsored noopener\" target=\"_blank\"\u003eCheck Pure TMG on DoNotAge\u003c\/a\u003e. Use BB10 for eligible reader savings.\u003c\/p\u003e","brand":"DoNotAge","offers":[{"title":"Default Title","offer_id":52576433701146,"sku":null,"price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1002\/8708\/6874\/files\/donotage-pure-tmg-366-capsules-supplied.png?v=1792304183","url":"https:\/\/biohackblueprint.org\/products\/pure-tmg-supplement","provider":"Biohack Blueprint","version":"1.0","type":"link"}